ADRENAL REGENERATION HYPERTENSION1

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Abstract
One adrenal was enucleated and the other removed in rats sensitized by unilateral nephrectomy and a high salt diet. This procedure resulted in severe hypertension, associated renal damage and some mortality. The response was not limited by sex nor size in the range of 60-160 g body weight. The syndrome resembled that produced by DCA (deoxycorticosterone acetate) but was accompanied by less pathological damage. Hydrocortisone, in doses which inhibited adrenal regeneration, did not prevent hypertension but seemed to modify the syndrome in ways not clearly defined, including a reduction of spontaneous NaCl intake. Hydralazine (Apresoline) reduced blood pressure when given either acutely or chronically but did not decrease salt intake, improve survival or minimize renal damage. Reserpine reduced blood pressure and saline appetite. It caused marked reduction in blood pressure when given acutely under conditions in which salt intake was controlled. Amphenone B did not inhibit the hypertensive response to adrenal regeneration.

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