THE ACTION OF ADRENALINE, ACETYLCHOLINE, AND HISTAMINE ON THE LUNGS OF THE RAT

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Abstract
1. The effects of adrenaline, acetylcholine and histamine on the blood‐vessels of the isolated perfused lungs of the rat were found to be as follows: Small doses of adrenaline (crystalline) cause pulmonary vasodilatation, and large doses cause vasoconstriction. If any effect on the bronchi takes place, it is one of dilatation. Both histamine and acetylcholine cause bronchoconstriction and vasoconstriction, but much larger doses are required to produce these effects in the rat than in the guinea‐pig.2. A constant infusion of adrenaline was found to increase the vasoconstrictor action of single injections of the same drug.3. The vasoconstrictor response of large doses of adrenaline is reversed by ergotoxine.I wish to thank Professor I. de Burgh Daly for his very generous help throughout this investigation.