Distribution and Turnover Rates of Radioactive Manganese in Various Tissues after Duodenal Dosing in Holstein Calves Fed a Practical-Type Diet2

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Abstract
Male Holstein calves, fed a practical-type diet with 32 ppm Mn, were sacrified 1, 4 or 12 hr. after a single tracer 54Mn dose was administered via duodenal catheter to study manganese metabolism. The results were compared with 65Zn data from an earlier study. Small intestinal tissues absorb 54Mn very rapidly and in amounts similar to 65Zn. However, the 54Mn release rate from intestinal tissue is much more rapid, with much of it apparently going back into the intestinal contents. The upper sections of the small intestine absorb far more 54Mn than the lower sections. Cecum and colon had high 54Mn concentrations. In other body tissues highest 54Mn concentrations were observed in liver and gall bladder. The abomasal tissue accumulated a substantial amount but far less than liver and gall bladder. Very low levels were detected in kidney, heart, spleen, muscle and testicle with blood concentrations below detectability limits. Tissues, other than digestive tract components, had far lower levels of 54Mn than observed earlier for 65Zn. Turnover rate of 54Mn in liver is much faster than that of 65Zn. The data suggest that 54Mn transport from the small intestine to the other body tissues, rather than intestinal uptake, is an important way by which the body keeps manganese concentrations much lower than zinc even though dietary intake is similar. Copyright © 1972. American Society of Animal Science . Copyright 1972 by American Society of Animal Science.

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