Carnitine palmitoyltransferase (CPT2) from liver mitochondrial inner membrane becomes inhibitable by malonyl‐CoA if reconstituted with outer membrane malonyl‐CoA binding protein
- 3 September 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 269 (2) , 406-408
- https://doi.org/10.1016/0014-5793(90)81204-2
Abstract
A soluble extract was obtained on treatment of rat liver mitochondrial outer membranes with cholate which bound (14C]malonyl‐CoA but was essentially free of carnitine palmitoyltransferase (CPT) activity. Extraction of mitochondrial inner membranes with cholate readily solubilized a CPT activity which was insensitive to malonyl‐CoA. Combination of these two extracts caused the CPT derived from inner membranes to become inhibitable by malonyl‐CoA.Keywords
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