Cytochemical and biochemical studies on neutrophil alkaline phosphatase in parents of trisomy 21 children
- 1 August 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 67 (3) , 313-316
- https://doi.org/10.1007/bf00291360
Abstract
A study of karyotypes and neutrophil alkaline phosphatase (NAP) was carried out for 66 parents (33 couples) of trisomy 21 children and for 60 control parents (30 couples). Enzyme activity was determined simultaneously by biochemical and cytochemical techniques. In the mothers of trisomy 21 children we found: (a) by biochemical techniques, a significant increase of NAP activity in polymorphonuclear leukocyte (PMN) homogenates (PPP<0.001) than in control mothers; in the fathers, the two techniques gave normal NAP activity results.This publication has 23 references indexed in Scilit:
- Impairment of Polymorphonuclear Functions in Hospitalized Geriatric PatientsGerontology, 1983
- Evidence that alkaline phosphatase from human neutrophils is the same gene product as the liver/kidney/bone isoenzymeClinica Chimica Acta; International Journal of Clinical Chemistry, 1982
- HEAT STABLE GRANULOCYTE ALKALINE PHOSPHATASES: NORMAL PREGNANCY AND SPONTANEOUS ABORTIONThe Lancet, 1981
- The ultrastructural localization of human neutrophil alkaline phosphatase in normal individuals during pregnancy and in patients with chronic granulocytic leukaemiaJournal of Molecular Histology, 1981
- Human alkaline phosphatases. Evidence of three isoenzymes (placental, intestinal and liver-bone-kidney-type) by lectin-binding affinity and immunological specificityBiochimica et Biophysica Acta (BBA) - Enzymology, 1980
- Evidence that three structural genes code for human alkaline phosphatasesNature, 1979
- Differential inhibition of the products of the human alkaline phosphatase lociAnnals of Human Genetics, 1978
- Leukocyte alkaline phosphataseAmerican Journal of Hematology, 1978
- Perspectives on alkaline phosphatase isoenzymesThe American Journal of Medicine, 1974
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971