A Microtechnique for Radioisotopic Determination of Glomerular Filtration Rate in Infants and Children

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Abstract
Our experience with a microtechnique using 99mTc-DTPA for determination of glomerular filtration rate in 172 children is presented. It is a simple finger-stick method carried out in a four-hour time period by trained nuclear medical per sonnel. The procedure meets all criteria for precise measurement of glomerular filtration rate, and the radiation dose is low. Proof of accuracy was obtained by comparison of this technique with concomitant 24-hour urinary creatinine clear ance in a subset of children.

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