The Effect of Soybean Sterols on the Absorption of Cholesterol by the Rat

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Abstract
Mixed soybean sterols (80 per cent sitosterols) were fed to rats simultaneously with cholesterol in acute and chronic experiments. In acute experiments, concurrent feeding of a test dose of soybean sterols and cholesterol did not diminish the usual fraction of cholesterol absorption into the thoracic duct lymph. In chronic experiments the addition of 2 or 10 per cent soybean sterols to a diet which induces chronic hypercholesteremia in rats failed to inhibit the development or magnitude of chronic hypercholesteremia.