Ultrasonodiagnosis of Subclinical Heart Failure by Increasing Afterload with Angiotensin II

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Abstract
In an attempt to diagnose latent heart failure, a transient increase of afterload to left ventricle was produced by angiotensin II, and the ventricular movement was assessed by echocardiography. Angiotensin II was administered in a dose of 0.075 .mu.g/kg body wt. Blood pressure was elevated by 40.5 .+-. 14.5 mmHg in 38 cases with latent heart failure and by 41.2 .+-. 4.5 mmHg in 30 normal subjects. Only in the former group was posterior wall excursion of left ventricle reduced from 11.4 .+-. 2.4 mm to 7.3 .+-. 2.3 mm and mean posterior wall velocity from 41.4 .+-. 10.1 mm/s to 26.5 .+-. 8.8 mm/s. The rates of these reductions were inversely correlated to the rate of elevation of left ventricular endodiastolic pressure as determined in 5 cases by cardiac catheterization. There was no change in 30 normal subjects. The usefulness of angiotensin-induced echocardiographic changes in detecting latent cardiac failure is indicated.

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