A potential role for apoptosis in neurodegeneration and Alzheimer's disease
- 1 February 1995
- journal article
- review article
- Published by Springer Nature in Molecular Neurobiology
- Vol. 10 (1) , 19-45
- https://doi.org/10.1007/bf02740836
Abstract
Previous studies have shown that β-amyloid (Aβ) peptides are neurotoxic. Recent data suggest that neurons undergoing Aβ-induced cell death exhibit characteristics that correspond to the classical features of apoptosis, suggesting that these cells may initiate a program of cell death. This chapter explores the criteria and precautions that must be applied to evaluate mechanisms of cell death in vitro and in vivo, discusses the evidence supporting an apoptotic mechanism of cell death in response to Aβ in cultured neurons, and describes potential correlations for these findings in the Alzheimer's disease brain. In addition, cellular signaling pathways that may be associated with apoptosis in response to Aβ are examined, and support for apoptosis as a mechanism of cell death for other neurodegeneration-inducing stimuli (e.g., oxidative injury) is described. The connection of multiple stimuli that induce neuronal cell death to an apoptotic mechanism suggests that apoptosis could play a central role in neurodegeneration in the brain.Keywords
This publication has 213 references indexed in Scilit:
- Methylmercury Induces Apoptosis of Rat Cerebellar Neurons in Primary CultureBiochemical and Biophysical Research Communications, 1994
- Transcription Factors′ DNA-Binding Activity in Rat Thymocytes Undergoing Apoptosis after Heat-Shock or Dexamethasone TreatmentBiochemical and Biophysical Research Communications, 1993
- Toxic effect of a β-amyloid peptide (β22–35) on the hippocampal neuron and its preventionNeuroscience Letters, 1993
- Studies of the relationship between cell proliferation and cell death. II. Early gene expression during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytesBiochemical and Biophysical Research Communications, 1992
- Vitamin E protects nerve cells from amyloid βprotein toxicityBiochemical and Biophysical Research Communications, 1992
- B- Amyloid increases neuronal susceptibility to injufy by glucose deprivationNeuroReport, 1991
- Glutamate triggers internucleosomal DNA cleavage in neuronal cellsBiochemical and Biophysical Research Communications, 1991
- Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's diseaseJournal of Molecular Biology, 1991
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991
- Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinBiochemical and Biophysical Research Communications, 1984