Analysis of Antigenic Variation in Cysticerci of Taenia solium

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Abstract
By studying the reactions and cross-reactions of antigen extracts from different collections of T. solium with their respective hyperimmune antisera, and by using numerical taxonomy to analyze the results, a measure of antigenic diversification within T. solium was established. Results varied somewhat depending on the immunological method employed. Double immunodiffusion and immunoelectrophoresis agreed in that all cysticerci were not identical, but shared .apprx. 1/3 of their antigens. Double immunodiffusion recognized 2 groups of identical cysticerci: one included 50% of the cysticerci and the other 21%. Immunoelectrophoresis was more discriminatory in that it recognized few extracts as identical. Electrophoretic data revealed that the most frequently shared antigen among cysticerci corresponded to that most frequently detected by immunologically responsive humans with cerebral cysticercosis. Antigen diversification of T. solium may provide a possible explanation of the pleomorphic immune response of man to this parasite.

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