Effect of Insulin on Clearance of Emulsified Fat from the Blood in Depancreatized Dogs.

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Abstract
Emulsified fat infused into pancreatectomized dogs is cleared from the blood at a normal rate if the animal is receiving insulin whereas without insulin the injected fat is cleared slowly. It thus appears that the clearance of fat from the blood is dependent upon normal carbohydrate utilization. Serum cholesterol levels rise following infusion of fat in diabetic animals deprived of insulin. Serum cholesterol concentration falls following infusion of fat into pancreatectomized animals receiving insulin. Observations on fat metabolism in which the fat is administered intravenously give data comparable to those obtained following oral administration of fat and the mechanisms of clearance seem identical by the two methods.