Renal function impairment caused by intravenous urography. A prospective study

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Abstract
Renal function was evaluated before and after i.v. urography (IVU) in 124 randomly selected patients. In cases with renal insufficiency (RI) (serum creatinine level, .gtoreq. 2 mg/dl), the incidence of renal impairment was higher (11 of 20 patients, 55%) than in the group without RI (16 of 104 patients, 15%). In the latter group, high blood pressure (BP) was associated with a higher frequency of renal impairment (28.6% vs. 10.5%). Advanced age, mild proteinuria and a single functioning kidney were not risk factors. The IVU preparation contributed to renal function impairment in 10 cases, while in the other 17 cases, the iodinated contrast material was the only factor apparently involved. Renal function returned to its previous level in a mean period of 12 days. One patient suffered progressive and irreversible renal failure and 2 others had a slight, persistent impairment of renal function. The incidence of renal function impairment was high but cases were usually mild and reversible. The most important factors were RI and high BP.

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