The Hepatitis of Hyperthermia

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Abstract
PATIENTS receiving intensive artificial fever therapy occasionally develop jaundice. This phenomenon has recently been reported as a major complication of therapeutic hyperthermia by several different groups of observers.1 2 3 In the reported series the incidence of jaundice has been as high as 19 per cent.3 The jaundiced patients follow a characteristic clinical course. Usually within the first twenty-four hours following fever, exaggerated nausea and vomiting occur. Within forty-eight hours the urine is dark and jaundice becomes apparent. There may be upper abdominal discomfort and tenderness over the liver. Fever, if present, is slight. In the great majority of cases the jaundice . . .