Lymphoid Antigens on Blast Cells in the Agranular Metamorphosis of Chronic Myelogenous Leukaemia

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Abstract
Undifferentiated blasts from a Ph’-positive chronic myelogenous leukaemia (CML) in terminal metamorphosis were reacted in an indirect ímmunofluo-rescence test with antilymphocytic globulins (AHLGs), raised against cultured lymphoblasts, thoracic duct and peripheral blood lymphocytes from healthy donors. After proper myeloid and/or monocytic absorptions the AHLGs interacted strongly with the undifferentiated blasts of CML, while this was not true for parallel controls with non-lymphoid leukaemias, both acute and chronic. The intensity of fluorescence, as determined by the use of a microfluorimeter, on these agranular blasts was comparable to the positivity of lymphoid cells from acute and chronic lymphatic leukaemias. These findings lend further support to the conception of a lymphoblast-like variety of terminal blastic crisis in chronic myelogenous leukaemia.

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