Regulation of Phosphatidylcholine Biosynthesis by the Methylation Pathway in Rat Pituitary Gland

Publisher Website
Google Scholar
Abstract
Rat pituitary extracts catalyze methylation of phosphatidylethanolamine to phosphatidylcholine using S-adenosyl-L-methionine as the methyl donor. In vitro incubation of hemipituitaries with 1 mM 2-methylaminoethanol led to a dose dependent de-crease in phosphatidylethanolamine methyltransferase activity as well as the incorporation of the radioactivity from [3H-methyl]-L-methionine into phosphatidyl-choline. The inhibitory effect of 2-methylaminoethanol was selective for phosphoiipids methylation since protein carboxymethyltransferase and catechol-o-methyltransferase activities were not affected.

This publication has 0 references indexed in Scilit: