RESPONSIVENESS OF FOETAL MOUSE TESTIS TO GONADOTROPHINS AT VARIOUS TIMES DURING SEXUAL DIFFERENTIATION

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Laboratoire de Chimie Hormonale Maternité de Port-Royal, 75014 Paris, France and †Centre de Recherches Endocrinologiques, Hôpital Cochin, 27 rue du Faubourg St-Jacques, 75014 Paris, France (Received 31 January 1977) It has been suggested that testosterone production by the foetal testis is under gonadotrophin control (Catt, Dufau, Neaves, Walsh & Wilson, 1975; Warren, Haltmeyer & Eik-Nes, 1975), but the particular roles of foetal pituitary and/or chorionic gonadotrophin are not clearly understood. We have previously demonstrated that a substance with both the biological and radioimmunological properties of luteinizing hormone (LH) is present in the pituitary gland of the male mouse foetus at 18 days of gestation (Pointis & Mahoudeau, 1976a, b). In the present work, we attempted to determine whether the pituitary gland of the male mouse foetus exhibits gonadotrophic activity during earlier stages of genital tract differentiation. On days 14-18 of gestation, the gonads and pituitary glands of male foetuses (Albino

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