The immediate vicinity of mouse metallothionein‐I gene contains two sites conferring glucocorticoid inducibility to the heterologous promoter
- 3 October 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 352 (3) , 339-341
- https://doi.org/10.1016/0014-5793(94)00980-5
Abstract
Glucocorticoid responsive elements (GREs) located −252 to −209 bp upstream and +1011 to +1054 bp downstream of the transcription initiation site of the mouse metallotionein-I (mMT-I) gene were identified in transient transfection eperiments. However, the promoter region of the mMT-I gene (−330 to +70 bp) was found to provide low, if any, glucocorticoid induction of the linked CAT gene, while showing strong cadmium regulation, comparable with the in vivo level.Keywords
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