Kinetic mechanism for the intestinal absorption of ofloxacin
- 1 March 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 40 (3) , 211-212
- https://doi.org/10.1111/j.2042-7158.1988.tb05223.x
Abstract
The absorptive behaviour of ofloxacin, a quinolone antibacterial agent, was studied following recirculation in small intestine of both male and female rats, at initial doses ranging from 0.125 to 5 mg mL−1. A saturable Michaelis-Menten process is suggested to explain the intestinal absorption. No significant differences were found in the absorption parameters per metabolic weight unit.This publication has 5 references indexed in Scilit:
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