Menazon as a Systemic Insecticide in Cattle1

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Abstract
Menazon® (S-(4,6-diamino-s-triazin-2-yl) methyl O,O-dimethyl phosphorodithioate) induced high levels of cattle grub control through systemic action. Lower limits of the effective dosage range were not established. Six successive daily rations of Menazon-fortified feed at dosage levels of 10 mg./kg./day gave complete control of larvae prior to encystment in three 350-pound Hereford calves. Topical applications of 1.5% spray to three similar animals were equally effective. Single oral doses of 25 mg./kg. and above proved toxic in young dairy calves while doses of 15 mg./kg. had no effect other than marked depression of erythrocyte cholinesterase activity. Topical application of Menazon in concentrations as high as 5% produced no side effects other than cholinesterase depression. When fed at the level of 10 mg./kg./day toxic reactions were not observed until after 4 to 5 days in young dairy calves and did not appear at all after six daily treatments of three 350-pound beef calves.

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