Complement‐dependent histamine release from rat peritoneal mast cells, induced by lipopolysaccharides fromBacteroides oralis, Fusobacterium nucleatumandVeillonella parvula

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Abstract
The capacity of phenol/water extracted lipopolysaccharides (LPS) from Bacteroides, Fusobacterium and Veillonella to induce histamine release from rat peritoneal mast cells was evaluated by a bioassay using atropinized guinea pig ileum and a fluorescence assay. Histamine release was completely complement dependent. The LPS of Veillonella have the greatest capacity to induce histamine release and Bacterioides have the weakest. [These findings may have relevance to the pathogenesis of periodontal disease.].