Alterations in the syntheses of RNA and DNA by chromium(III) in regenerating rat liver.

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Abstract
The administration of trivalent chromium (Cr (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was accumulated in the liver cell nuclei and concentrated in the nucleoli. Of RNAs synthesized in the nuclei, nucleolar RNA synthesis was most enhanced by the administration of Cr (III). Furthermore, DNA synthesis in the Cr (III)-administered rat liver after partial hepatectomy was initiated a little earlier and was less synchronized than in control rats.

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