Inhibition of Glyceraldehyde-3-Phosphate Dehydrogenase by Follicle-Stimulating Hormone Preparations In Vitro
- 1 January 1970
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 2 (06) , 349-351
- https://doi.org/10.1055/s-0028-1095052
Abstract
Rabbit muscle GAPDH (E.C.1.2.1.12) was inhibited by two preparations of FSH, one ovine and the other porcine. A third preparation, also of ovine origin, did not inhibit this enzyme. This suggested that the inhibition was not due to FSH but a contaminant. This inhibition of glyceraldehyde-3-phosphate dehydrogenase was specific. None of the other pituitary hormones had any effect on this enzyme and other NAD-linked and NADP-linked dehydrogenases were not inhibited by these FSH preparations. Abbreviations used ADH = alcohol dehydrogenase EDTA= disodium ethylenedinitrilotetracetate FSH = follicle-stimulating hormone GDH = L-glutamic dehydrogenase G6PDH = glucose-6-phosphate dehydrogenase GAPDH = glyceraldehyde-3-phosphate dehydrogenase LH = luteinizing hormone α-MSH = α-melanocyte-stimulating hormone 6PGDH = 6-phosphogluconate dehydrogenase STH = growth hormone TSH = thyroid-stimulating hormoneKeywords
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