Changes in [Ca2+]i Induced by Rapid Cooling of Single Skeletal Muscle Fibres Treated with Low Concentration of Caffeine
- 1 January 1984
- book chapter
- Published by Springer Nature
- Vol. 170, 565-568
- https://doi.org/10.1007/978-1-4684-4703-3_50
Abstract
In single skeletal muscle fibres treated with low concentration of caffeine, lowering the bathing solution temperature from 18°C to below 7°C increased [Ca2+]i in three phases depending on caffeine concentration and temperature. Tension could be fully developed (rapid cooling contracture, RCC) by the second phase of the released Ca2+. The second and third phases were inhibited by low concentrations of procaine, and the first phase was blocked by a higher one. RCC was observed even in Ca2+-free solution. The mechanism of [Ca2+]i changes and RCC during cooling was discussed.Keywords
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