Magnetic resonance imaging and neurosphere therapy of stroke in rat
- 2 January 2003
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 53 (2) , 259-263
- https://doi.org/10.1002/ana.10467
Abstract
We intracisternally transplanted subventricular zone (SVZ) cells labeled by ferromagnetic particles into stroked rats. Migration of transplanted cells was non‐invasively tracked using magnetic resonance imaging (MRI). We found that transplanted cells selectively migrated towards the ischemic parenchyma at a mean speed of 65 ± 14.6 μm/hr in living rats. Migration of transplanted cells in the brain was also measured histopathologically. Rats transplanted with SVZ cells exhibited significant improvement of neurological function. Our data suggest that intracisternal transplantation of SVZ cells provides an avenue for cell therapy of stroke and that MRI can be used to track grafted cells in the brain. Ann Neurol 2003Keywords
This publication has 12 references indexed in Scilit:
- A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemiaJournal of Neuroscience Methods, 2002
- Cell therapy in Parkinson's disease – stop or go?Nature Reviews Neuroscience, 2001
- Multicolor “DiOlistic” Labeling of the Nervous System Using Lipophilic Dye CombinationsNeuron, 2000
- Recovery recapitulates ontogenyTrends in Neurosciences, 2000
- Transplanted CNS stem cells form functional synapses in vivoEuropean Journal of Neuroscience, 2000
- Chapter 1 The subventricular zone: source of neuronal precursors for brain repairPublished by Elsevier ,2000
- Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelinationProceedings of the National Academy of Sciences, 1999
- Neural transplantation for neurodegenerative disordersThe Lancet, 1999
- Diffusion-, T2-, and Perfusion-Weighted Nuclear Magnetic Resonance Imaging of Middle Cerebral Artery Embolic Stroke and Recombinant Tissue Plasminogen Activator Intervention in the RatJournal of Cerebral Blood Flow & Metabolism, 1998
- Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brainCell, 1991