The department of veterans affairs' unique clinical cancer research effort

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Abstract
Without organized clinical trials, we are doomed to repeat our mistakes endlessly. There are many genuine conflicts of interest intrinsic to clinical research. Some of these arise from the necessity of admitting that we as physicians do not know the best way to treat every disease or each patient and that all treatments currently available for this patient's disease are suboptimal. With humility and honesty, these conflicts of interest can be overcome. Surmounting other more palpable ones, however, is equally challenging. Supporting the participation of our patients in clinical trials requires a practical reconfiguration of practice patterns, different and more record keeping, and the surrender of autonomy. Each of these facts has economic implications. Practitioners who are paid according to the specific services they provide risk both significant income loss and cost increase by participating in clinical trials. The Department of Veterans Affairs is a charter member of the cancer clinical trials establishment and the originator of a long string of important firsts in cancer research. The nature of the VA system eliminates or diminishes the impact of many of the conflicts of interest that hinder clinical trial participation. This globally budgeted comprehensive system, which theoretically is responsible for the care of more citizens than is the entire Canadian national health service, is an unique clinical research resource. Some of the high points of the VA contributions to cancer treatment development are listed in this paper. Hopefully, this overview makes the point that the VA clinical research enterprise is a treasure that can ask critical questions that, because of irresolvable economic conflicts of interest, can be asked neither in the fee-for-service nor the prepaid health maintenance settings. This clinical cancer research resource must be nurtured and supported, and it must continue to address critical questions that it alone can answer.

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