PHARMACOLOGICAL PROFILE OF A POTENTIAL HYPNOTIC COMPOUND RU-31158

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 240  (1) , 53-65
Abstract
RU 31158, demonstrated potent hypnotic activity compared to diazepam when examined in the mouse and rat. RU 31158 potentiated minimal hypnosis in mice induced by both hexobarbital and chlorprothixene with ED50 values of 2.15 (1.53-3.01) and 0.69 (0.46-1.02) mg/kg p.o. [orally] respectively; these compared to values for diazepam of 17.00 (11.25-25.67) and 3.60 (2.25-5.76) mg/kg p.o. RU 31158 also potentiated hexobarbital in the rat with an ED50 value of 1.2 (0.7-2.0) mg/kg p.o. as compared to 32.0 (27.5-38.5) mg/kg p.o. for diazepam. Sleep studies in the rat confirmed the hypnotic properties of RU 31158, and showed that the duration of action at 8.0 and 16.0 mg/kg p.o. was not longer than 9 hours. RU 31158 showed potent minor tranquilizer, anxiolytic and anti-convulsant properties in a series of pharmacological tests.