Increased Frequency of Multiple Primary Melanomas in Hereditary Familial Melanoma

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Abstract
Multiple primary melanomas can be observed in a frequency of 1–4% in melanoma patients, while they obviously occur more frequently in hereditary familial melanoma. In every 8th patient with an – in itself rare – hereditary familial melanoma a development of two or more primary melanomas has to be expected. Casuistically, a family is reported where a 14-year-old girl died of malignant melanoma, whose mother later on developed two primary malignant melanomas in an interval of 2 years.