Early growth and coronary heart disease in later life
- 8 September 2001
- Vol. 323 (7312) , 572
- https://doi.org/10.1136/bmj.323.7312.572
Abstract
# Analysis was flawed {#article-title-2} EDITOR—Eriksson et al concluded that in Finnish men born 60 years ago “low weight gain during infancy is associated with increased risk of coronary heart disease,” yet they did not analyse infant weight gain.1 All their references to infant growth relate to size at 1 year (table 3). Had they applied the key regression models that we have described2 to separate the effects of weight at different ages on later outcome, they would have found that infant weight gain was unrelated to risk of coronary heart disease. In their simultaneous analysis the hazard ratios for birth weight and weight at 1 year were similar and less than 1, showing that greater weight during infancy is protective. Weight gain is weight at 1 year less weight at birth, so if weight gain were protective it would appear as a protective effect of weight at 1 year and a relatively deleterious effect of weight at birth. …Keywords
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