Celiac Disease — How to Handle a Clinical Chameleon
- 19 June 2003
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 348 (25) , 2568-2570
- https://doi.org/10.1056/nejme030050
Abstract
Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye, and barley) in genetically susceptible persons. The disease is associated with HLA-DQ2 in 90 to 95 percent of cases and with HLA-DQ8 in 5 to 10 percent of cases and is self-perpetuating in the continued presence of gluten.1 It is the interplay between genes (both HLA and other types) and environment (i.e., gluten) that leads to the intestinal damage that is typical of the disease.2 Under physiologic circumstances, this interplay is prevented by competent intercellular tight junctions, structures that limit the passage of macromolecules . . .Keywords
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