Proportion of Early E Rosettes Formed by Peripheral Blood Lymphocytes from Young and Aged Subjects

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Abstract
The absolute number and percentage of early E-rosette-forming cells were determined in blood of young and aged subjects. The assay was carried out at low temperature (+ 4°C) for 30 min in phosphate-buffed saline without any supplementation. The results indicate that both the absolute number and the percentage of early E rosettes detected are age-dependent, showing a tendency of reaching higher values in both aged females and males. There were also sex-related differences between young males and young females, but the values for aged males and females were approximately the same. The significance of the above-described early E rosette values is discussed and compared with early E rosettes detected by other methods.