THE INFLUENCE OF pH ON THE ACTIVITY OF NICOTINE AT THE NEUROMUSCULAR JUNCTION

1 January 1963

journal article
research article
Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology

Vol. 41 (1) , 283-289
https://doi.org/10.1139/y63-036

Abstract

The effects of pH on the activity of nicotine relative to that of nicotine monomethiodide was studied on the frog rectus abdominis preparation. Results were obtained which substantiate the view that it is the univalent nicotinium ion, rather than the un-ionized base, which acts at the neuromuscular junction.