Host-Range Properties of Murine Xenotropic and Ecotropic Type-C Viruses
- 1 February 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (2) , 423-426
- https://doi.org/10.1093/jnci/56.2.423
Abstract
Host-range properties of xenotropic (x-tropic) and ecotropic mouse type-C viruses were determined.NB-tropic viruses replicated only in mouse and rat cells, whereas x-tropic viruses, which do not exogenously infect mouse cells, grew in cells from various other mammalian species. Great variability in susceptibilities to x-tropic viruses was demonstrated in cells frOm heterologous species and in cells from a single species (human). Although rat cells were susceptible to both types of viruses, hamster cells were uniformly resistant. In addition, the x-tropic viruses crossed class barriers to infect cells of avian species but not insect, fish, or reptile cells.Keywords
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