Silver-catalyzed cyclization of acetylenic alcohols and acids: a remarkable accelerating effect of a propargylic C–O bond
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 23 (8) , 803-805
- https://doi.org/10.1039/a903587g
Abstract
The heteroannulation catalyzed by silver salts of alkynols 1, 2 or alkynoic acids 3 is considerably enhanced by the presence of a propargylic C–O bond. This method allows for a rapid access to highly functionalized heterocycles, such as α-methylene oxolanes 4 or oxanes 5 and as γ-methylene pentanolactones 6.Keywords
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