Studies on the Metabolism of Human Placental Lactogen in Pregnancy

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Abstract
The metabolic characteristics of HPL have been investigated by means of a radio-immunoassay. The highest concentration of this trophoblastic hormone was found in maternal blood and, to a lesser extent, amniotic fluid. The activity in umbilical cord blood was negligible, no HPL could be detected in fetal urine. The titres in maternal urine were about 150 times lower than in the serum, the mean renal clearance was 0.0057 ml/min. After surgical removal of the placenta HPL disappeared very quickly from the maternal blood; after one hour the mean concentration was only 10-21%. The biological half-life was estimated to be approximately 21 minutes, the daily production rate more than 0.5 g. No circadic rhythms were found. The significance of these findings is discussed.

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