INHIBITION OF HUMAN ANTIGEN-SPECIFIC T CELL PROLIFERATION BY ANTI-T BLAST SERA

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Abstract
Two rabbit antisera, one raised against activated human T lymphoblasts and one raised against the human T cell line HPB-ALL, have the ability to inhibit antigen-induced T cell proliferation. Antiproliferative activity is absorbed by T blasts and HPB-ALL cells, but not by B lymphoblastoid cell lines, .alpha.-ethylisothiouronium bromide-treated sheep red blood cell receptor-negative lymphoid cells, or the human T cell lines MOLT-4 leukemia and HSB. The effects of these antisera do not require the presence of complement and are not attributable to toxicity during culture. The F(ab'')2 fragment of anti-T blast antiserum is also active.