EFFECTS OF HYPOPHYSECTOMY AND AGE ON THE INFUNDIBULAR NUCLEUS IN MAN

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Abstract
SUMMARY: Cell density, length of the infundibular complex and size of the neuronal nuclei were measured in a group of patients surviving hypophysectomy after breast cancer, and in a group of patients without hypophysectomy. Hypophysectomy decreased the length of the infundibular cell complex and the mean size of the neuronal nuclei and caused an increase in the difference between the cell density of the posterior and anterior part of the cell complex. In the hypophysectomized patients the mean nuclear size of neuronal nuclei and the length of the cell complex increased with survival time. These findings are interpreted as showing shrinkage of the infundibular nucleus after hypophysectomy. A return to normal values and possibly increased activity occur with survival times over 95 days. The significance of the marked correlation between decrease of supraoptic cell population and the increase of mean nuclear size in the infundibular neurones of the hypophysectomized patients is discussed. In both groups the mean nuclear size of the infundibular neurones increased with age. The significance of this finding is discussed.

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