Influence of Benzyl-Imidazoline on the Peripheral Circulation of Man.

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Abstract
Seventy male subjects without evidence of peripheral vascular disease, between the ages of 18 and 45 (avg. 26) and 10 subjects with organic obliterative disease, between the ages of 35 and 55 (avg. 51) were studied. Of the latter 7 had arteriosclerosis obliterans and 3 thromboangiitis obliterans. The volume change of the digits was determined using the Cambridge pneumo-pleth-ysmograph and the 2d toe tip and right or left index finger tip were enclosed in a digital cup from which volume changes were recorded. Intraven. benzylimidazoline effectively increased the rate of blood flow to the periphery in normal individuals and in certain patients with arteriosclerotic obliterative disease. The volume change of the digits following venous occlusion and the skin temps. were augmented to a greater degree in the lower extremities than in the upper. The amplitude of pulsation showed less change than did the skin temp. or volume changes of the digits. The greatest rise in temp. was seen in the toes. The temp. of the skin of the calf, subcut. tissues, and deep muscle of the calf showed a decreasing temp. effect in this order. The rectal temp. and temp. of the forehead showed the least change. Benzylimidazoline was not effective in raising the skin temp. of the foot, forehead, or hand after indirect heating of one arm. Benzylimidazoline shock was seen on 2 occasions.