Effect of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on the immediate and delayed hypersensitivity reactions.
- 1 January 1979
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 29 (5) , 733-744
- https://doi.org/10.1254/jjp.29.733
Abstract
Effects of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on experimental models of the type I-IV allergic reactions were studied in comparison with those of disodium cromoglycate (DSCG), dexamethasone and other agents. AA-344 showed inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. It had slight or little effect on the Forssman shock in guinea pigs, the complement-dependent cytolysis of mast cells in rats, the Arthus reaction in guinea pigs and the tuberculin reaction and the contact sensitivity in mice. DSCG was less effective, using these experimental models. Dexamethasone showed a suppressive effect on type III and IV allergic reactions. The results indicate that AA-344 selectively suppresses the type I allergic reaction.This publication has 0 references indexed in Scilit: