SULFONAMIDES: PASSAGE INTO SPINAL FLUID AND RECTAL ABSORPTION

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Abstract
Sulfathiazole, when given by mouth, entered normal spinal fluid to a conc, of only about 20% of the simultaneous blood conc; roughly twice this conc. would penetrate through inflamed meninges. Sulfapyridine and sulfanilamide penetrated more efficiently into the spinal fluid in meningitis, the concs. in the spinal fluid approaching the blood levels of these drugs. Rectal absorption of sulfapyridine and sulfathiazole was practically nil in dogs and patients. Rectal absorption of sulfanilamide, although variable, was always considerable, and. when low blood concs. will suffice, rectal adm. may be a valuable method for therapeutic adm. of this drug.

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