Glutathione S-Transferase Activity, Sulfhydryl Group and Glutathione Levels, and DNA Cross-Linking Activity With Chlorambucil in Chronic Lymphocytic Leukemia
- 2 May 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 82 (9) , 776-779
- https://doi.org/10.1093/jnci/82.9.776
Abstract
Glutathione (GSH) levels and glutathione S-transferase (GST) activities were measured in the leukemia cells of 12 patients with chronic lymphocytic leukemia. Both were correlated with prior clinical exposure to alkylating agents and with DNA cross-link formation by chlorambucil in these cells in vitro. No correlation was observed between prior exposure to alkylating agents and GSH level or GST activity. An inverse correlation was observed between GST activity and cross-linking by chlorambucil, which was enhanced if both GST activity and GSH level were related to cross-linking. These findings suggest that the combination of GST and GSH protects the DNA of leukemia cells from chlorambucil, but the role of this combination in clinical resistance remains to be determined. (J Natl Cancer Inst 82: 776–779, 1990)Keywords
This publication has 1 reference indexed in Scilit:
- Chronic Lymphocytic LeukemiaAnnals of Internal Medicine, 1985