Clinical Experience with Long‐term Bendroflumethiazide Treatment in Calcium Oxalate Stone Formers

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Abstract
Bendroflumethiazide was administered to 85 patients (62 men, 23 women) with recurrent calcium oxalate stone disease. Side effects leading to interrupted treatment were observed in 26 (31%) of the patients; 59 (40 men, 19 women) remained on treatment for a mean (.+-. SD) period of 3.7 .+-. 1.0 yr, and 21 reported late side effects. Patients (20) were given 2.5 mg bendroflumethiazide daily (group A), 27 were given 2.5 mg twice daily (group B), and 12 were given 5 mg once daily (group C). Eight patients (14%) formed new stones and another 2 demonstrated stone growth during treatment. A beneficial effect on stone formation was observed in groups B and C but not in group A. Patients who failed to respond to treatment had a pretreatment stone formation rate of 0.74 stones/yr compared with 0.22 in those who did not form new stones. Those with recurrence during treatment had a lower citrate excretion than other patients. No effect on urinary citrate was recorded during treatment and longterm treatment with bendroflumethiazide did not affect oxalate excretion.