Effects of parathyroid hormone on total protein, calcium, magnesium, phosphorus, sodium and potassium concentrations of normal human parotid saliva

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Abstract
The effects of parathyroid hormone (PTH) administered to 6 young normal adult subjects on protein, Ca, Mg, P, Na and K concentrations in parotid saliva were studied in relation to the salivary flow rate. Stensen''s duct was cannulated and excretion patterns of the constituents determined before and after stimulation of saliva production by lemon juice. After a control period (period 1), 50 U[units] of PTH were given i.v. followed by an infusion of 2 U/min for 60-90 min (period 2). In the absence of any detectable changes in plasma, PTH induced a significant rise of salivary protein, Ca and P concentrations at rest and following lemon juice stimulation, and of Na concentration, but only at high flow rates for the latter. PTH did not change Mg and K excretion significantly. Control experiments without PTH were performed on 5 other subjects. Protein, P and K concentrations did not change significantly between period 1 and period 2. Ca and Na excretion were reduced and Mg excretion increased during period 2. PTH probably acts on the parotid gland by affecting protein secretion and electrolyte transport. Possible mechanisms of these changes are discussed.

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