Evaluation of the SOS chromotest for the detection of antimutagens
- 1 January 1991
- journal article
- Published by Wiley in Environmental and Molecular Mutagenesis
- Vol. 17 (4) , 258-263
- https://doi.org/10.1002/em.2850170407
Abstract
The SOS chromotest was applied for the detection of antimutagens. To raise SOS induction, the bacteria were treated with the mutagens, UV, 4‐nitroquinoline N‐oxide (4NQO), N‐methyl‐N′‐nitro‐N‐nitroso‐guanidine (MNNG), or benzo[a]pyrene (B[a]p). The inhibitory effects of L‐ascorbic acid, glutathione, vanillin, 5‐fluorouracil (5‐FU), 5‐chlorouracil (5‐CU), cobaltous chloride, sodium selenite and sodium arsenite, which are known as antimutagens, were investigated with their addition either simultaneously or post treatment time. It became clear that the SOS chromotest was very useful for the detection of antimutagens.Keywords
This publication has 20 references indexed in Scilit:
- Antimutagenic effects of benzaldehyde and its derivatives on mutagenesis induced by 4-nitroquinoline 1-oxide in Escherichia coli.Agricultural and Biological Chemistry, 1988
- SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicalsMutation Research Letters, 1987
- Effects of vanillin on sister-chromatid exchanges and chromosome aberrations induced by mitomycin C in cultured Chinese hamster ovary cellsMutation Research Letters, 1987
- Antimutagenic effects of 5-fluorouracil and 5-fluorodeoxyuridine on UV-induced mutagenesis in Escherichia coliMutation Research Letters, 1986
- Antimutagenic action of cobaltous chloride on Trp-P-1-induced mutations in Salmonella typhimurium TA98 and TA1538Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1982
- Antimutagenic effect of selenium on acridine orange and 7,12-dimethylbenz[a]anthracene in the Ames Salmonella/ microsomal systemMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1981
- Effect of cobaltous chloride on spontaneous mutation induction in a Bacillus subtilis mutator strainMutation Research Letters, 1981
- Effect of sodium selenite and methyl methanesulfonate or N-hydroxy-2-acetylaminofluorene co-exposure on sister-chromatid exchange production in human whole blood culturesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- Reduction of N-methyl-N'-nitro-N-nitrosoguanidine- Induced Mutations by Cobalt Chloride in Escherichia ColiProceedings of the Japan Academy, Series B, 1978
- Inhibitory effects of selenium on the mutagenicity of 2-acetylaminofluorene (AAF) and AAF derivativesCancer Letters, 1977