Incidence of Haemophilus influenzae type b meningitis during 18 years of vaccine use: observational study using routine hospital data
Open Access
- 25 November 2004
- Vol. 330 (7481) , 18-19
- https://doi.org/10.1136/bmj.38301.657014.79
Abstract
This increase in failure coincided with the change from whole cell pertussis to combined three component acellular vaccine (DTaP-Hib). This combination lowers Hib antibodies.3 The clinical significance is unclear. Acellular vaccine cannot be blamed in the Netherlands, where whole cell vaccine was still used.4 Both countries have been giving Hib vaccination at age 2, 3, and 4 months; a booster at 11 months is given in the Netherlands. Another characteristic in the United Kingdom is concomitant meningococcal group C conjugate. Replacement of serotypes other than Hib in severe diseases has also raised concern.Keywords
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