Transmission of the Virus of Poliomyelitis to Mice
- 29 March 1935
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 81 (2100) , 319-320
- https://doi.org/10.1126/science.81.2100.319
Abstract
Mice, which are not susceptible to infection with the virus of poliomyelitis, were given short, repeated x-ray treatments to reduce their resistance and were then injected with the virus. In two series of mice indistinct clinical symptoms were obtained in the first passage following a long incubation period. After the second passage the symptoms became more definite. The pathology in the infected mouse was found mainly in the brain and meninges. The infectious agent in mouse brains could be transmitted from mouse to mouse, from mouse to monkey, and back to the mouse. The virus in the mouse was filterable through Seitz filters and neutralized by anti-poliomyelitic serums.This publication has 4 references indexed in Scilit:
- Attempts to Produce Poliomyelitis in Refractory Laboratory Animals.Experimental Biology and Medicine, 1935
- Active Immunization in Monkeys Against Poliomyelitis with Germicidally Inactivated VirusThe Journal of Immunology, 1935
- Micro Mounts, Reverse and ConverseScience, 1934
- Respiratory Types and PhotoperiodismScience, 1934