The Mechanism of Ketotifen-Induced Histamine Release from Human Peripheral Leucocytes
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 68 (2) , 176-178
- https://doi.org/10.1159/000233090
Abstract
Ketotifen-induced histamine release from human leucocytes is independent of extracellular calcium and does not require metabolic energy. Furthermore, histamine release is accompanied by a loss of cellular cytoplasmic contents. This suggests that the mechanism of ketotifen-induced histamine release at high concentrations is non-specific and is similar to that of clemastine, a typical H1 antagonist.Keywords
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