Thrombasthenia in Liver Disease

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Abstract
IMPAIRMENT of the hemostatic mechanism is a common experience in active disease of the liver. Several recent reports1 2 3 4 have stressed the multiplicity of plasma clotting factors that may be deficient, as well as the frequency of reduction in the number of platelets. The occurrence of a functional platelet defect in hepatic disorders has been largely ignored.5 On review of the results of the thromboplastin-generation test as applied routinely to a variety of diseases with either frank or suspected bleeding tendency, a defect in thromboplastin activity of platelets was noted to be more common than thrombocytopenia in cirrhosis. Because of the . . .