Effects of Dibutyryl Cyclic AMP and Propranolol on Renin Secretion in Dogs

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Abstract
The effect of c[cyclic]AMP and Db[dibutyryl]cAMP on renin secretion and renal hemodynamics was studied in anesthetized dogs. The infusion of cAMP into a renal artery failed to increase renin secretion significantly, but DbcAMP caused a significant increase in renin secretion. Both cAMP and DbcAMP had a vasodilator effect on renal vessels, without any change in renal blood pressure. These 2 compounds differed in their effects on GFR [glomerular filtration rate] and urine flow. cAMP infusion transiently decreased GFR without significant effects on urinary flow and urinary Na excretion, but DbcAMP increased GFR, urinary flow and urinary Na excretion. Time course studies indicated that there was no direct relationship between renin secretion and RBF [renal blood flow] or urinary Na excretion during DbcAMP infusion. The .beta.-adrenergic blocking agents, propranolol and sotalol, decreased both arterial and renal venous PRA [plasma renin activity], but failed to affect the DbcAMP-induced renin secretion. These findings suggest that the effect of hbcAMP on renin secretion. These findings suggest that the effect of DbcAMP on renin secretion is associated with its action on JGC [juxtaglomerular cells] and not with electrolyte or renal hemodynamic changes.

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