Selective N,N-functionalisation of cyclam: crystal structure of the Cu2+ complex of 1,4,8,11-tetra-azacyclotetradecane-1,8-diacetic acid and the tricyclic lactam 15,18-dioxo-1,5,8,12-tetra-azatricyclo[10.2.2.25.8]tetradecane
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1094-1095
- https://doi.org/10.1039/c39880001094
Abstract
A general synthetic method for the synthesis of 1,8-disubstituted derivatives of the 14-membered tetra-aza macrocycle, ‘cyclam’, involves selective ditosylation: in the Cu2+ complex of the 1,8-diacetic acid derivative, the copper is six-co-ordinate with elongated Cu–O interactions and this macrocycle undergoes lactamisation to form a paracyclophane-like tricyclic lactam which is resistant to acidic hydrolysis.Keywords
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