Enantioselective Radical Addition/Trapping Reactions with α,β-Disubstituted Unsaturated Imides. Synthesis ofanti-Propionate Aldols
- 3 February 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (8) , 2390-2391
- https://doi.org/10.1021/ja043371e
Abstract
This manuscript describes a highly diastereo- and enantioselective intermolecular radical addition/hydrogen atom transfer to α,β-disubstituted enoates. Additionally, we show that anti-propionate aldol-like products can be easily prepared from α-methyl-β-acyloxyenoates in good yields and high diastereo- and enantioselectivities.Keywords
This publication has 8 references indexed in Scilit:
- Current progress in the asymmetric aldol addition reactionChemical Society Reviews, 2004
- Enantioselective Conjugate Radical Addition to β‐Acyloxy Acrylate Acceptors: An Approach to Acetate Aldol‐Type ProductsAngewandte Chemie International Edition in English, 2003
- Enantioselective Radical ProcessesChemical Reviews, 2003
- Diastereoselective Magnesium Halide-Catalyzed anti-Aldol Reactions of Chiral N-AcyloxazolidinonesJournal of the American Chemical Society, 2001
- Enantioselective Tandem Radical Reactions: Vicinal Difunctionalization in Acyclic Systems with Control over Relative and Absolute StereochemistryJournal of the American Chemical Society, 2001
- Asymmetric Synthesis of β-Amino Acid Derivatives via Catalytic Conjugate Addition of Hydrazoic Acid to Unsaturated ImidesJournal of the American Chemical Society, 1999
- Enantioselective Free Radical ReactionsAccounts of Chemical Research, 1998
- A Catalytic Asymmetric Synthesis of 11-Deoxy-PGF1α Using ALB, a Heterobimetallic Multifunctional Asymmetric ComplexThe Journal of Organic Chemistry, 1998